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Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors

Radotinib (IY5511HCL), a novel and selective BCR-ABL1 tyrosine kinase inhibitor, has shown pre-clinical and phase I activity and safety in chronic myeloid leukemia.This phase II study investigated the efficacy and safety of radotinib in Philadelphia chromosome-positive chronic phase-chronic myeloid leukemia patients with resistance and/or intoleran

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Transcriptomic analysis of differentially expressed genes in the oviduct of Rhacophorus omeimontis provides insights into foam nest construction

Abstract Background The production of foam nests is one of the strategies that has evolved to allow some anuran species to protect their eggs and larvae.Despite considerable knowledge of the biochemical components of and construction wella 6r terracotta behavior leading to anuran foam nests, little is known about the molecular basis of foam nest co

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